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  • Writer's pictureJeff Lundgren

Ketamine Assisted Psychotherapy: A Promising Treatment for Depression and PTSD


Ketamine-assisted psychotherapy is emerging as a powerful new treatment option for people struggling with severe depression, anxiety, and PTSD. Unlike traditional antidepressants, which can take weeks or months to work (if they work at all), ketamine can provide rapid relief from symptoms in just hours or days. Here's an overview of this groundbreaking therapy.


What is Ketamine?

Ketamine is an FDA-approved anesthetic used safely for decades in medical procedures. In low, sub-anesthetic doses, ketamine profoundly affects brain networks impacted by mood disorders. It rapidly restores connections between brain cells damaged by chronic stress, trauma, and depression.


How Does Ketamine Therapy Work?

Ketamine is unlike traditional antidepressants, which target serotonin, norepinephrine, or dopamine. Ketamine acts on the brain's NMDA receptors and stimulates the regrowth of synapses (connections between brain cells). This leads to a rapid reduction in depression and anxiety symptoms for most patients.


Significantly, the psychedelic effects of ketamine induce a brain state amenable to therapy. Ketamine temporarily disrupts rigid, negative thought patterns, allowing more flexible, optimistic thinking to take root. This is why ketamine therapy is most effective when combined with psychotherapy.


The Ketamine Therapy Process

Ketamine therapy typically involves three components:

  1. Preparation session - The patient meets with the therapist, and goals for the experience are discussed. Patients are coached on how to get the most out of the ketamine experience. Here is where we answer questions, help learn, and guide the client, laying the road map for their clinical experience.

  2. Ketamine session - The patient receives a single sub-anesthetic dose of ketamine. At Oak Branch Counseling, we primarily use oral lozenge. This lasts around 90 minutes. They experience an altered state of consciousness with psychedelic effects. The therapist is present to guide the experience.

  3. Integration session - This debriefing occurs 1-2 days after the ketamine session. The patient discusses the experience and integrates any insights into their mental health issues. Further psychotherapy focuses on sustaining progress.

An experienced team must carefully tailor protocols. Ketamine is powerful medicine, and appropriate safeguards are required to minimize risks and maximize benefits. But when appropriately administered, ketamine therapy can be life-changing for many.


The Origins of Ketamine

Ketamine was first synthesized in the 1960s and approved by the FDA in 1970. Initially used as a battlefield anesthetic in the Vietnam War, ketamine's antidepressant properties weren't discovered until the 1990s. In recent years, an explosion of research into ketamine therapy has led to its widespread adoption. Though not yet fully understood, ketamine's unique mechanisms make it a game-changer for treating mood disorders.


Promising Applications

Ketamine therapy has shown dramatic efficacy for treatment-resistant depression, anxiety, and PTSD. It provides rapid and robust relief, even for patients who have tried multiple medications unsuccessfully. Ketamine is bringing new hope to many who assumed their mental health conditions would never improve.


Ketamine-assisted psychotherapy is shedding new light on the nature of mental illness and redefining what successful treatment looks like. When combined with therapy, ketamine can catalyze transformational healing. This innovative modality will likely become a frontline treatment for mood disorders in the years ahead.

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